Abstract

A Zika virus disease outbreak occurred in Roatán, Honduras, during September 2015–July 2016. Blood samples and clinical information were obtained from 183 patients given a clinical diagnosis of suspected dengue virus infection. A total of 79 patients were positive for Zika virus, 13 for chikungunya virus, and 6 for dengue virus.

Highlights

  • A Zika virus disease outbreak occurred in Roatán, Honduras, during September 2015–July 2016

  • Zika virus is closely related to dengue virus (DENV), which is endemic to Roatán, the largest Honduran Bay island, located 50 km north of the Honduras mainland [6]

  • We report emergence of Zika virus on Roatán

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Summary

History of infectious diseases

Multivariable analysis showed that rash (odds ratio [OR] 30.6, 95% CI 10.8–86.9) and headache (OR 11.2, 95% CI 2.7–46.7) were independently associated with Zika virus infection. Fever (OR 0.44, 95% CI 0.26–0.74) and vomiting (OR 0.25, 95% CI 0.08–0.73) were associated with a decreased risk for Zika virus infection (Table 2). Alternative body fluids (e.g., saliva, urine, whole blood) were not available for testing, and serologic testing for Zika virus was not performed because of cost constraints and cross-reactivity between Zika virus and DENV antibodies. We did not perform confirmatory testing of CHIKV- and DENV-positive samples. This study could be biased for detecting Zika virus and not DENV/CHIKV because of use of a more sensitive assay

Conclusions
Sign or symptom
Findings
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