Abstract
PurposeThe outcome of radiotherapy is a direct consequence of the dose delivered to the patient. Yet image-guidance and motion management to date focus on geometrical considerations as a practical surrogate for dose. Here, we propose real-time dose-guidance realized through continuous motion-including dose reconstructions and demonstrate this new concept in simulated liver stereotactic body radiotherapy (SBRT) delivery. Materials and methodsDuring simulated liver SBRT delivery, in-house developed software performed real-time motion-including reconstruction of the tumor dose delivered so far and continuously predicted the remaining fraction tumor dose. The total fraction dose was estimated as the sum of the delivered and predicted doses, both with and without the emulated couch correction that maximized the predicted final CTV D95% (minimum dose to 95% of the clinical target volume).Dose-guided treatments were simulated for 15 liver SBRT patients previously treated with tumor motion monitoring, using both sinusoidal tumor motion and the actual patient-measured motion. A dose-guided couch correction was triggered if it improved the predicted final CTV D95% with 3, 4 or 5 %-points. The final CTV D95% of the dose-guidance strategy was compared with simulated treatments using geometry guided couch corrections (Wilcoxon signed-rank test). ResultsCompared to geometry guidance, dose-guided couch corrections improved the median CTV D95% with 0.5–1.5 %-points (p < 0.01) for sinusoidal motions and with 0.9 %-points (p < 0.01, 3 %-points trigger threshold), 0.5 %-points (p = 0.03, 4 %-points threshold) and 1.2 %-points (p = 0.09, 5 %-points threshold) for patient-measured tumor motion. ConclusionReal-time dose-guidance was proposed and demonstrated to be superior to geometrical adaptation in liver SBRT simulations.
Highlights
The outcome of radiotherapy is a direct consequence of the dose delivered to the patient
We propose real-time dose-guidance and demonstrate this concept in simulated stereotactic body radiotherapy (SBRT) delivery in the liver, where dose is highly susceptible to motion
In the treatment simulations without couch corrections, the final clinical target volume (CTV) DD95% was predicted with highest accuracy for the sinusoidal motion (root-mean-square error (RMSE) below 0.5 %-points) and lowest accuracy for the Calypso motion (RMSE of 2.00 %points) (Fig. 2)
Summary
The outcome of radiotherapy is a direct consequence of the dose delivered to the patient. Results: Compared to geometry guidance, dose-guided couch corrections improved the median CTV D95% with 0.5–1.5 %-points (p < 0.01) for sinusoidal motions and with 0.9 %-points (p < 0.01, 3 %-points trigger threshold), 0.5 %-points (p = 0.03, 4 %-points threshold) and 1.2 %-points (p = 0.09, 5 %-points threshold) for patient-measured tumor motion. Image-guided radiotherapy (IGRT) typically uses purely geometrical considerations as a practical surrogate for the more clinically relevant quantity of dose when aligning daily setup images with simulation images [1]. More complex situations arise in case of deformations such as differential motion of multiple targets or organs-at-risk (OAR) that hinder perfect alignment of all structures simultaneously To address this issue, researchers have investigated the concept of dose-guided patient setup, where the dosimetrically optimal patient position is calculated based on the anatomy of the day. Substantial anatomical changes occur intrafractionally [8], potentially deteriorating the delivered dose
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