Real-time Classification of Brain States in Functional MRI Using Dynamic Connectivity Patterns and Machine Learning

Abstract

Understanding real-time brain states facilitates deeper insights into cognitive processes, emotional responses, and neurological phenomena. It provides researchers with a dynamic view of brain function, aiding in the development of novel therapies, advancing neuroscience, and fostering innovations in brain-computer interfaces and artificial intelligence. The research aims to achieve real-time classification of brain states using dynamic connectivity patterns and Convolutional Neural Network (CNN) algorithms. It focuses on how demographic variables, such as brain volume and medication usage, influence classification accuracy. The study employs Python programming with FSL and Nilearn for preprocessing tasks like motion correction and dynamic connectivity pattern extraction. Feature selection and data partitioning are managed using Scikit-learn, ensuring standardized feature values and handling missing data. The CNN architecture is customized to handle spatial and temporal features in functional MRI (fMRI) data, with convolutional layers extracting spatial features representing local connectivity patterns. Dynamic connectivity matrices visualization aids in understanding brain network reconfigurations over time. This approach offers real-time insights into cognitive processes and neurological disorders, guiding personalized interventions for brain health. In result, connectivity matrices and 3D brain network visualizations are pivotal for unraveling brain state dynamics. Connectivity matrices unveil intricate interactions among brain regions across resting, task execution, and stress response states, offering quantitative insights into functional connectivity patterns. Meanwhile, 3D visualizations provide spatial representations, showcasing complex interplays and architectural changes across states.