Abstract
Highly elastic tissues have proven resistant to fractionation via focused ultrasound (fUS); however, our previous work in rat tendon has demonstrated a small window of parameters conducive to mild mechanical disruption. For therapeutic applications, there is a need to assess the extent of fUS-induced mechanical bioeffects in real time in order to avoid over- or under-treatment. Here, elastic collagen hydrogels (TeloCol®-10), as well as healthy and collagenase-soaked ex vivo bovine tendons, were exposed to fUS at 1.1–3.68 MHz (p + ≤ 127 MPa, p− ≤ 35 MPa) using 10-ms pulses repeated at 1 Hz. Cavitation signals were collected using simultaneous passive cavitation imaging (PCI) and passive cavitation detection (PCD) to monitor fUS treatment in real time. Preliminary data in polyacrylamide hydrogels and ex vivo bovine tendon show no consistent trends between simultaneous PCI and PCD signals; this is potentially due to different orientations of the receiving transducers, which we will further investigate. However, neither PCI nor PCD trends were consistently linked to a mechanical bioeffect. Therefore, we are exploring the addition of Doppler ultrasound to PCI/PCD to help link the fUS exposure to the desired bioeffect. [Work supported by NIHR01EB032860]
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