Abstract
Plant coumarins are important components of the human diet and a number of them are considered to possess chemo-preventive and therapeutic properties against cancer. Scopoletin, a natural coumarin component has been shown to inhibit the growth of many cancer cells. In this study, the cytotoxic activity of scopoletin was studied against human neuroblastoma cells SH-SY5Y. The activity of scopoletin was evaluated by Sulphorhodamine B (SRB) assay and xCELLigence system. It was demonstrated that scopoletin reduced human SH-SY5Y neuroblastoma cell viability. Scopoletin inhibited the growth of the cell line and the IC50 values were 91.82 and 79.19 μM for 48-h and 72-h, respectively. The findings from this study demonstrated that the growth inhibitory and cytotoxic effects of scopoletin on SH-SY5Y cells may prove essential in the development of novel treatment regimens for neuroblastoma cancer.
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