Abstract
Abstract Priming immunization of DBA/1 strain of mice with dinitrophenylated Ascaris antigen (DNP-Asc) in alum and supplemental immunization with ovalbumin (OA) prepared the animals to give a typical secondary anti-hapten antibody response to DNP-OA with respect to both IgE and IgG antibodies. The results showed collaboration between carrier-specific helper cells and hapten-specific memory cells for anti-hapten IgE antibody response. Priming with DNP-Asc alone significantly enhanced anti-DNP IgE and IgG antibody response to DNP-OA. Enhancement of the antibody response to the DNP-heterologous carrier was due to proliferation of DNP-specific memory cells by priming with DNP-Asc. Evidence was obtained that the DNP-specific memory cells collaborated with helper cells specific for secondary carrier to show the enhanced anti-hapten antibody response.
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