Reading auditory discrimination behaviour of freely moving rats from hippocampal EEG

Abstract

It has been suggested that hippocampal rhythmical slow activity (theta rhythm) is related to cognitive process and the genesis of P300 response. To test this hypothesis, hippocampal EEG data from CA1 were recorded from rats trained to perform auditory discrimination oddball paradigm. In well-trained rats, significant changes in the hippocampal theta rhythm were observed during an auditory oddball paradigm. Here we used an artificial modular neural network with wavelet coefficients to investigate whether changes in the hippocampal theta rhythm are related to cognition of right tone objectively. However, an objective data interpretation with the modular neural network does not support the hypothesis that changes in theta rhythm are related to cognitive process. In addition, it was confirmed that changes in task-related theta rhythm before/after learning the auditory oddball paradigm resulted from the fact that training changed the character of the motor behaviour.