Abstract
Abstract Osteoarticular complications are a major concern in patients treated with long-term hemodialysis, hemofiltration or continuous ambulatory peritoneal dialysis. Uremic chronic patients, treated for long periods of time (≥15 years) with hemodialysis, could develop a new kind of osteoarthropathy due to amyloidosis characterized by abnormal distribution of beta-2 microglobulin (B2M) in joint tissue. Deposits of B2M are responsible for several lesions, clinically evident in different pathologies, such as: carpal tunnel syndrome, spondylarthrosis, and hemodialysis osteoarthropathy.
Highlights
The pathogenesis of dialysis arthropathy, still unknown, is probably multifactorial
Radiological evidence of articular complications is apparent in hips with massive infiltration of amyloid deposits
Immuno-peroxidase studies revealed the presence on intracellular hemosiderin [7,8]
Summary
The pathogenesis of dialysis arthropathy, still unknown, is probably multifactorial. A group of associated factors, including duration of dialysis, type of dialysis membrane, patient’s age, effects of hyperparathyroidism on the skeletal system, presence of apatite crystals, and an aluminum and iron overload may play a role [1,2,3,4,5,6].
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