Abstract
In a larger better-defined migraine population, Domínguez et al.1 replicated a report from almost 2 decades earlier of increasing periaqueductal gray matter (PAG) iron deposition being linked to a phenotypic shift from episodic to chronic migraine.2 This concept had proven controversial3 because iron deposition specific to the PAG was not restudied until now. Altered iron homeostasis in PAG leads to its dysfunction4 (e.g., PAG failing to activate during headache implicates aberrant modulation of nociceptive drive).2,5 With this in mind, further analysis of the associations between PAG iron and allodynia of record in the present clinical population might prove interesting.
Published Version
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