Abstract
Abstract. The comprehensive clinical-immunological characteristic of a tick-borne encephalitis vaccine En-cepur Adult (Germany), which was studied on a group of residents of Far East of Russia was discussed. Reactogenity in 32,4% of vaccinees was characterized by minor clinical manifestations and was due to the reaction to specific vaccine albumin. Expression of immune response (mean geometric titers) was evaluated in a neutralization test. A group with the reactogenity showed higher geometric mean antibody titers (1:182) compared with a group without the reactogenity (1:97). All of vaccinees with various levels (high, middle, low) of specific immune response had an increased quantity of CD20+ and CD25+ lymphocytes. We showed a difference in immunologic reactivity of people with high and low levels of specific antibody response. As compared with a low level group the group with a high level of specific response showed significantly higher quantity of lymphocytes and their subpopulations (CD3+, CD4+, CD45RA+) as well as higher levels of IgM, IgG. We conclude that vaccine Encepur Adult (Germany) possesses a high immunologic activity. It is recommended to use this vaccine as a safe and effective specific preventive remedy in TBE endemic areas.
Highlights
В последние годы на юге Дальнего Востока, как и на всей эндемичной по клещевому энцефалиту территории России, отмечен значительный подъем заболеваемости клещевым энцефалитом (КЭ)
We showed a difference in immunologic reactivity of people with high and low levels of specific antibody response
Zent O., Banzhoff A., Hilbert A.K., Meriste S., Sluzewski W., Ch. Wittermann Safety, immunogenici ty and tolerability of a new pediatric tick borne enceph alitis (TBE) vaccine, free of protein derived stabilizer // Vaccine
Summary
РЕАКТОГЕННОСТЬ ВАКЦИНЫ ПРОТИВ КЛЕЩЕВОГО ЭНЦЕФАЛИТА «ЭНЦЕПУР® ВЗРОСЛЫЙ» И ИММУННЫЙ ОТВЕТ НА ЕЕ ВВЕДЕНИЕ. Дана клинико иммунологическая характеристика вакцины против клещевого энцефалита (КЭ) «Энцепур взрослый» (Германия), изучение которой проведено на контингенте людей, проживающих на Дальнем Востоке России. As compared with a low level group the group with a high level of specific response showed significantly higher quantity of lymphocytes and their subpopulations (CD3+, CD4+, CD45RA+) as well as higher levels of IgM, IgG. В последние годы на юге Дальнего Востока, как и на всей эндемичной по клещевому энцефалиту территории России, отмечен значительный подъем (более чем в 3 4 раза) заболеваемости клещевым энцефалитом (КЭ). Целью настоящей работы явилось изучение кли нико иммунологической реакции организма на вве дение новой вакцины против клещевого энцефали та «Энцепур взрослый» (Германия) группе лиц, проживающих на юге Дальнего Востока
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