Reactogenicity and Safety of DTPa Vaccine and Haemophilus influenzae Type b Conjugate Vaccine (Hib) in a Single Injection vs DTPw and Hib as Separate Injections as a Booster Vaccination in 18-Month-Old Children

Abstract

Objective To compare the reactogenicity and safety of the administration of diphtheria-tetanus-acellular pertussis (DTPa) and Haemophilus influenzae type b conjugate (Hib) vaccines in one injection with those of the simultaneous administration of diphtheria-tetanus-whole cell pertussis (DTPw) and Hib vaccines in opposite limbs as booster doses to 18-month-old children previously primed with three doses of DTPw and Hib vaccines as a primary vaccination course.