Abstract

The biochemical nature of the cross-reactive antigens on murine B cells, detected with xenogeneic antihuman Ia (H.Ia) sera, were examined. These antigens, coded for by the I-C subregion, were found to be carbohydrate in nature and probably exist as glycolipids on the cell surface. Furthermore, sugar inhibition studies demonstrated that the anti-H.Ia sera recognized identical monosaccharide residues on murine and human B cells.

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