Abstract
This is a summary of a lecture presented at the 100th Anniversary, Moissan Symposium in Paris on Friday 10th November 2006. In HF/SbF 5, Vinca alkaloids react selectively at the D’ring of the molecule. In the presence of CHCl 3 (or CCl 4), vinorelbine yields 20′,20′-difluoro-3′,4′-dihydrovinorelbine (vinflunine), presently in phase III experimentation for treatment of bladder cancer and non small cell lung cancer.
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