Abstract

A new protocol was developed for the synthesis of 2,3-dihydroimidazo[1,2-<i>c</i>]pyrimidines, based on an intramolecular reaction between a pyrimidine nitrogen atom and an acetal moiety in the presence of boron trifluoride etherate. The method was expanded to permit the synthesis of the triheterocyclic imidazo[1,2-<i>c</i>]pyrazolo[4,3-<i>e</i>]pyrimidine system.

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