Abstract
An ester of 4-hydroxyaminoquinoline- 1-oxide ( 4-HAQO), the O,O'-diacetyl derivative (diAc- 4-HAQO), was previously considered as a possible ultimate metabolite of the carcinogen 4-nitroquinoline- 1-oxide ( 4-NQO). In order to verify such a hypothesis we have carried out a fluorescent comparative study between the in vitro diAc- 4-HAQO reacted DNA and the in vivo 4-HAQO and 4-NQO modified DNA. Our results show that diAc- 4-HAQO could be used as a model of ultimate carcinogen of 4-NQO.
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