Abstract
Liver cells during chemical carcinogenesis (3′-methyldimethylaminoazobenzene) and cells of primary hepatomas retain the property of reacting to partial hepatectomy by increased incorporation of3H-thymidine into DNA, just as under normal conditions this process is inhibited by dexamethasone. The inducibility of tyrosine aminotransferase (EC 2.6.1.5) likewise remained unchanged, whereas induction of tryptophan pyrrolase (EC 1.13.11.11) in primary hepatomas was abolished. The adequacy of a model of chemical carcinogenesis of an organ if the heterogeneity of its cell populations is disregarded is discussed.
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