Abstract
AbstractMethyl (3,6‐dichloropyridazin‐4‐yl)acetate (II), prepared from methyl (3,6‐dihydroxypyrid‐azin‐4‐yl)aeetate (1) by chlurination with phosphorus oxychloride, was used for studies of nucleo‐philic displacement reactions and it has been found that only the chlorine atom at position 6 was displaced with hydrazine. With diluted hydrochloric acid both chlorine atoms were displaced with the 6‐oxo isomer predominating. By turning the aromatic ring of pyridazine into an o‐quinoid system, the chlorine atom at position 3 became mobile. Cyelization of (6‐hydrazino‐s‐triazolo‐[4,3‐b ]pyridazin‐7‐yl)acetic acid hydrazide (XIX) gave 6‐aminopyrrolo[3,2‐e ]s‐triazlo[ 4,3‐b ]‐pyridazm‐7(8H)one (XXI).
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