Abstract
AbstractThe reactivity of 4‐(1‐butoxyvinyl)‐2H‐chromen‐2‐one (1) and (E)‐4‐(2‐butoxyvinyl)‐2H‐chromen‐2‐one (2) as diene in thermal Diels–Alder cycloaddition reactions with several electron‐poor dienophiles is reported. Among several dienophiles used in this study 1,4‐benzoquinone afforded cycloadducts 11‐butoxy‐1H‐naphtho[1,2‐c]chromene‐1,4,5‐trione (3e) and 1H‐naphtho[1,2‐c]chromene‐1,4,5‐trione (4g) that showed Cdc25 phosphatase‐inhibition activity at low micromolar values, with both compounds more effective against Cdc25 A and Cdc25 C isoforms.
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