Abstract
We read “Reactive Retinal Astrocytic Tumors (So-called Vasoproliferative Tumors): Histopathologic, Immunohistochemical, and Genetic Studies of Four Cases” by Poole Perry and associates. 1 Poole Perry L.J. Jakobiec F.A. Zakka F.R. et al. Reactive retinal astrocytic tumors (so-called vasoproliferative tumors): histopathologic, immunohistochemical, and genetic studies of four cases. Am J Ophthalmol. 2013; 155: 593-608.e1 Abstract Full Text Full Text PDF PubMed Scopus (39) Google Scholar They report histopathology following enucleation in 4 cases. They accurately demonstrated that the lesions were composed of glial cells (mostly astrocytes) with scarcity of blood vessels. Their observations confirm other reports demonstrating that end-stage retinal vasoproliferative tumors following failed conservative treatments are composed predominantly of glial cells. They showed a fundus photograph of 1 case in which enucleation was performed 16 months after cryotherapy and many intravitreal injections of bevacizumab. We suspect that these treatments, designed to reduce tumor vascularity, were responsible for the histopathologic findings of extensive gliosis. Reactive Retinal Astrocytic Tumors (So-called Vasoproliferative Tumors): Histopathologic, Immunohistochemical, and Genetic Studies of Four CasesAmerican Journal of OphthalmologyVol. 155Issue 3PreviewTo evaluate the cellular nature of and diagnostic terminology used in connection with acquired retinal “vasoproliferative tumors.” Full-Text PDF ReplyAmerican Journal of OphthalmologyVol. 156Issue 1PreviewThe term retinal vasoproliferative tumor (VPT, or what we call reactive retinal astrocytic tumor) was initially applied to the entity under discussion by J. Shields, and we can appreciate the Shieldses' ongoing attachment to it. We do not wish, however, to be drawn into a sterile, medieval scholastic debate about terminology, but rather would like to keep the focus on understanding the underlying biology. Full-Text PDF
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