Abstract
Reactive Plasticity with a Kainate Receptor Twist: Rhythmic Firing in Granule Cells Breaks down the Gate?
Highlights
Synaptic Kainate Receptors in Interplay With INaP Shift the Sparse Firing of Dentate Granule Cells to a Sustained Rhythmic Mode in Temporal Lobe Epilepsy
Epilepsy Currents, Vol 12, No 4 (July/August) 2012 pp. 153–154 © American Epilepsy Society new synaptic connections—often with cells to which they had sparse or no connection before. These events have been especially well-documented in the rodent dentate gyrus, where myriad studies have shown that, coincident with development of spontaneous seizures, new glutamatergic synapses form between granule cells, increasing their overall excitability
Glutamate released from sprouted mossy fiber terminals results in enhanced excitatory neurotransmission in the dentate gyrus after synaptic reorganization [2], a result consistent with increased activity of NMDA and non-NMDA receptors, and a phenomenon that has been extensively studied for more than two decades
Summary
These events have been especially well-documented in the rodent dentate gyrus, where myriad studies have shown that, coincident with development of spontaneous seizures, new glutamatergic synapses form between granule cells, increasing their overall excitability. Glutamate released from sprouted mossy fiber terminals results in enhanced excitatory neurotransmission in the dentate gyrus after synaptic reorganization [2], a result consistent with increased activity of NMDA and non-NMDA receptors, and a phenomenon that has been extensively studied for more than two decades.
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