Abstract
Background: Tumor recurrence is the main cause of poor prognosis of GBM. Finding the characteristics of recurrent GBM that provide early warning of tumor recurrence can provide guidance for the clinical treatment of recurrent GBM.Results: Reactive oxygen species (ROS) biosynthetic processes was significantly elevated in recurrent GBM. The recurrent risk score based on the ROS biosynthetic process was closely related to tumor purity and tumor immune functions. The quantitative risk assessment system could be used to predict the recurrence time of GBM. Gallic acid, a compound with high anti-oxidation activity and low cytotoxicity, was screened as a potential chemotherapy sensitizer for recurrent GBM.Conclusion: The quantitative risk assessment system based on ROS biosynthetic process could be used for early warning of GBM recurrence. Combination of low-dose gallic acid and temozolomide could improve therapeutic outcomes in recurrent GBM.Methods: A total of 663 primary and recurrent GBM samples with clinical and microarray data were included in this study. GSVA, LASSO-COX, and Kaplan-Meier survive curve were performed to construct and verify a quantitative risk assessment system for GBM recurrence prediction. An antioxidant capacity test and cell viability test were used to discover potential drugs for recurrent GBM.
Highlights
Glioblastoma (GBM) is the most common and highly lethal malignancy of the central nervous system [1]
The quantitative risk assessment system based on Reactive oxygen species (ROS) biosynthetic process could be used for early warning of GBM recurrence
Reactive oxygen species biosynthetic processes were highly enriched in recurrent GBM
Summary
Glioblastoma (GBM) is the most common and highly lethal malignancy of the central nervous system [1]. We have found that even after aggressive treatment, the recurrence of GBM is almost inevitable. Lack of effective treatment for recurrent GBM is one of the main causes of poor prognosis [3, 4]. A mechanistic understanding of early warning signals that predict recurrence may help to prolong the survival of GBM patients. Tumor recurrence is the main cause of poor prognosis of GBM. The quantitative risk assessment system could be used to predict the recurrence time of GBM. Conclusion: The quantitative risk assessment system based on ROS biosynthetic process could be used for early warning of GBM recurrence. GSVA, LASSO-COX, and Kaplan-Meier survive curve were performed to construct and verify a quantitative risk assessment system for GBM recurrence prediction.
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