Abstract
Reactive Oxygen Species: From Harmful Molecules to Fine-Tuning Regulators of Stem Cell Niche Maintenance.
Highlights
In plants, our knowledge on reactive oxygen species (ROS) function in stem cell niche maintenance is much more limited
To understand how ROS regulate these processes at the molecular level, the authors investigated the expression of different genes involved in maintaining quiescence center (QC) status, stem cell activity, or PLOS Genetics | DOI:10.1371/journal.pgen
They analyzed the level of two key transcription factors (TFs) needed to define root distal stem cell niche, SCARECROW (SCR) and SHORT ROOT (SHR). Both SCR and SHR were down-regulated in app1 mutants and in wild-type roots with reduced levels of H2O2 and O2, suggesting that ROS levels control the expression of these TFs
Summary
Our knowledge on ROS function in stem cell niche maintenance is much more limited. App1 has similar root meristem size and root growth as the wild type, these mutants displayed higher cell division rates of QC cells and premature distal stem cell (DSC) differentiation. They analyzed the role of ROS in stem cell maintenance by altering ROS levels in wild-type roots.
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