Abstract
A spontaneous reactive mesothelial hyperplasia occurred in a female, 15.7-year-old African green monkey (grivet; Chlorocebus aethiops). At necropsy, massive effusions were found in the abdomen, the thorax, and the pericardium. Additionally, multiple small, beige-gray nodules were detected on the serosal surfaces of the abdominal organs. Histopathologically, the mesothelial cells resembled the epithelioid subtype of a mesothelioma, but no infiltrative or invasive growth could be demonstrated. The mesothelial cells on the thoracis, liver, and intestinal serosa were accompanied by chronic serositis. Mesothelial cells expressed cytokeratin, vimentin, calretinin, desmin, Wilms Tumor 1 (WT-1) protein, and epithelial membrane antigen (EMA). Cells were negative for carcinoembryonic antigen (CEA), cluster of differentiation 15 (CD15), and podoplanin. Ultrastructurally, cells revealed a moderate amount of microvilli of medium length, perinuclear tonofilament bundles, and long desmosomes. In fluorescence in situ hybridization (FISH) for the detection of characteristic gene loss (p16; CDKN2A), NF2, and MTAP, no deletions were detected. No asbestos fibers and no presence of Simian virus 40 antigen (SV40) could be demonstrated.
Highlights
Introduction and literature overview1.1 Mesothelial hyperplasiaMesothelial hyperplasia is a benign, reactive condition with no neoplastic potential that is associated with a variety of chronic and acute injuries to the mesothelial surface (Watkins et al, 2018)
Mesothelial hyperplasia is a benign, reactive condition with no neoplastic potential that is associated with a variety of chronic and acute injuries to the mesothelial surface (Watkins et al, 2018)
For the fluorescence in situ hybridization (FISH), formalinfixed and paraffin-embedded material was sectioned at 2 μm, deparaffinized, and digested with pepsin for 15 min prior to another fixation
Summary
Mesothelial hyperplasia is a benign, reactive condition with no neoplastic potential that is associated with a variety of chronic and acute injuries to the mesothelial surface (Watkins et al, 2018). Mesothelial cells might undergo hyperplasia as a response to serositis (Barth et al, 1997). It may manifest as small white nodules (Watkins et al, 2018). Reactive mesothelial proliferations may mimic mesothelioma because they may show high cellularity, numerous mitotic figures, cytologic atypia, necrosis, papillary growth, and entrapment of mesothelial cells within fibrosis mimicking invasion (Husain et al, 2018)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
