Abstract
Reactive follicular hyperplasia (RFH) in lymph nodes is characterized by an increased number and size of lymphoid follicles. Lymphoid follicles are the functional units of the B-cell immune response and, as a result, inflammatory and immune reactions that trigger a humoral response and cause activation of B-cells are generally associated with reactive follicular hyperplasia. In broad terms, diseases that cause RFH include bacterial and viral infections, as well as autoimmune diseases. In some patients, the etiology of RFH cannot be ascertained. Follicular hyperplasia is commonly accompanied by hyperplasia of other compartments in the lymph node.
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