Abstract
AbstractThe reactive extraction of 6‐aminopenicillanic acid (6‐APA) from aqueous buffer solution has been studied using a liquid anion exchanger, tricaprylylmethyl ammonium chloride (Aliquat‐336) in n‐butyl acetate as the solvent. The extraction equilibrium constant and partition coefficient increase with increase in pH up to a limiting value of pH, beyond which extraction decreases due to coextraction of OH− and buffer anions and hydrolytic decomposition of 6‐APA. The experimental data could be predicted from an equilibrium model which takes into account the ideal behaviour of the two liquid phases. The coextraction of the buffer anion under low pH conditions was found to be negligible. The extraction rate measured in a stirred cell of constant interfacial area appears to be dependent on the interfacial mass transfer of the reactive species as well as on the interfacial reaction through its dependence on the concentration of 6‐APA in the aqueous and organic phases, respectively.
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