Abstract
Methyl α-methoxyimino acetoacetate, an intermediate of cephalosporin antibiotics, was produced through chemical reaction and crystallization. Because the crystal purity was influenced remarkably by both the chemical reaction and crystallization rates, high-purity crystals were obtained only by the optimum combination of the two rates. The effect of agitation on the chemical reaction rate and crystal quality was studied by consideration of mechanisms in reactive crystallization processes. It was confirmed that the Z factor, showing power consumption ratio of agitation, can be used to estimate crystal purity, yield, size distribution and scale-up effect for this reactive crystallization system.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
