Reactive Chromatography: A Review of Process Technology

Rajendra Bhaskar Bhandare

doi:10.11648/j.ajche.20190701.11

Abstract

Chemical Industries are primarily intended for conversion of raw materials into desired products. It develops new products for human lives. The challenge for chemical companies is to cut their costs. The chemical industries have high rate of technological change. Chemical industries use separate processes for converting raw material into product. Now day’s the technology that is adopted is reactive separation. In this technology, the emphasis is given on combining separate units in one single unit. Advantageous of this technology is like reducing energy use, increase efficiency etc. Reactive separation uses different techniques like Reactive Chromatography, Reactive Distillation and Reactive Extraction, Reactive Membrane Separation, Reactive Crystallization. Out of this, Reactive chromatography is a attractive alternative since it employs differences in adsorption - desorption of chemical reagents on external solid phase, which can also act as catalyst. It is possible to obtain high purity of product from this process, also downstream purification is reduced or even eliminated. Fixed bed reactor or simulated bed reactors are mainly used for this purpose. Many researchers have studied reactive chromatography. This review is focused in development in reactive chromatography processes.

Highlights

Chemical Industries are the primarily, intended for conversion of raw materials into desired products that we use in our daily life
If there is no significant difference between the operating conditions of reaction and separation, the combination of reaction and separation is Rajendra Bhaskar Bhandare: Reactive Chromatography: A Review of Process Technology not possible
It is alternative to reactive distillation when the reaction involves non - volatile and temperature sensitive component, as is the case of pharmaceutical industry, a reaction occurs inside a chromatographic column catalyzed by a catalytic adsorbent, and the product is separated by the difference in the affinity to the same catalytic adsorbent packed in the column

Summary

Introduction

Chemical Industries are the primarily, intended for conversion of raw materials into desired products that we use in our daily life. Some of advantage of reactive separation are by using reaction to improve separation (overcoming azeotropes, while others are realized by using separation to improve reactions (increasing rates, overcoming equilibrium limitations, minimizing side reaction) As both operations occur in the same unit, there must be match between pressure and temperature. If there is no significant difference between the operating conditions of reaction and separation, the combination of reaction and separation is Rajendra Bhaskar Bhandare: Reactive Chromatography: A Review of Process Technology not possible. It has few inherent disadvantages like new technology, limited application, extensive experimental development, complex modeling requirement.

Reactive Chromatography

Principle of Reactive Chromatography

Case Studies of Reactive Chromatography

Findings

Conclusion