Reactive changes in the rat spinal cord in experimental neuropathy with and without magnetic stimulation

Abstract

Performing an experiment in which electronically microscopically studied the nature of reactive changes in the structural thin section of the spinal cord, as well as their dynamics during transcranial magnetic stimulation for 1 month after experimental neuromesis and after compression-ischemic neuropathy of the sciatic nerve. The reported development of compensatory-restorative processes in neurons, glial cells and the microvasculature of the lumbar spinal cord in rats that receive treatment with transcranial magnetic stimulation has been established. It was shown, that in all groups of rats changes in the structures of the lumbar thickening of the rat spinal cord developed in the form of depletion of the cytoplasm, destruction of organelles, changes in the nuclei and development of apoptosis of neurons and glial cells, destruction of the membranes and axial cylinders of myelin fibers. Moreover, these changes are more pronounced in groups after experimental neuromesis. However, in groups of rats, both after compression-ischemic neuropathy and after experimental neuromesis after treatment with transcranial magnetic stimulation, there were signs of the development of recovery processes in the form of intracellular repair of neurons, proliferation of oligodendrocytes, restoration of the structure of myelin fibers and capillaries, and the absence of free red blood cells in the extracellular space. The obtained morphological data confirm the effectiveness of treatment of transcranial magnetic stimulation of injuries of the peripheral nervous system in relation to neurons, glial cells, myelin and non-myelin fibers of the spinal cord.