Abstract
Organophosphorus nerve agents cause neurotoxicity through the inhibition of acetylcholinesterase (AChE) in the human body. Various oxime reactivators were found to reactivate the inhibited AChE. Pralidoxime (2‐PAM) is one such representative oxime antidotes. However, its reactivation ability, as well as its action on the inhibited AChE of the central nervous system, is not sufficient, and therefore the discovery of new oxime reactivators is required. Here, oximes with N‐bromoalkyl groups were synthesized, and their reactivation potency on AChE inhibited by paraoxon was evaluated.
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