Abstract
ABSTRACT During treatment for malignant disease with antimetabolites a few instances of photosensitivity have been reported. This phenomenon was studied experimentally in patients receiving methotrexate for psoriasis. An acute dermal inflammation was elicited through repeated exposure to ultraviolet light during the days preceding a single intravenous injection of the drug. When ultraviolet light was given four days before methotrexate, or simultaneously with the injection, the regular rise and slope of inflammatory intensity was registered in the skin. When ultraviolet light was given one or two days before the injection of methotrexate the drug influenced the course of inflammation towards a diphasic curve. Thus, methotrexate when administered in proper time reactivates a receding inflammatory process. It is concluded that exacerbations of irradiation erythema in patients on cancer chemotherapy provide examples of “false photosensitivity”.
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