Abstract
Abstract3‐Arylacrylonitrile‐2‐thiocarboxamides (1a–d) reacted with S‐methylisothiourea to give 4‐amino‐6‐aryl‐2‐methylmercaptopyrimidine‐5‐carbonitriles (3a–d). The products 3a–d were also obtained via the reaction of 3‐arylacrylonitrile‐2‐carbonitriles (4a–d) with S‐methylisothiourea. Compounds 4a–d reacted with thiourea and urea to yield 4‐amino‐6‐aryl‐2‐mercaptopyrimidine‐5‐carbonitriles (5a–d) and 2‐hydroxy derivatives (5e–h) respectively. Oxidation of 5a–d with hydrogen peroxide afforded 5e–h. 5a–h were readily alkylated with methyl iodide to give 3a–d.
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