Abstract
Summary 1. Two cases of pneumococcal pneumonia had mild, reversed, passive anaphylaxis from small doses of antiserum. Each had an excess of circulating polysaccharide. 2. Effective hyposensitization is described. 3. Antiserum should be given slowly and in small increments when circulating polysaccharide is present. Therapeutic doses of antiserum should not be given until the circulating polysaccharide has been neutralized by the small increments of antiserum.
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