Abstract
Nitrite and SCN− in saliva can mixes with H2O2 in the stomach. The mixing can result in the formation of ONOOH. It is not yet known how salivary SCN− reacts with ONOOH. An objective of the present study was to elucidate the reaction between ONOOH and SCN− . In nitrite/H2O2 systems at pH 2, SCN− inhibited the consumption of nitrite and the formation of . SCN− enhanced the decomposition of ONOOH and H2O2 in HNO2/H2O2 systems. Accompanying the reactions, sulfate was formed, suggesting that ONOOH oxidized SCN− . SCN− inhibited the nitration of phenolics induced by HNO2/H2O2. The inhibition is discussed taking SCN− -dependent reduction of ONOOH to HNO2 into consideration. SCN− also inhibited H2O2-induced consumption of nitrite and nitration of phenolics in acidified saliva. The result obtained in this study suggests that salivary SCN− can reduce ONOOH to /HNO2 inhibiting nitrating reactions in the stomach.
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