Abstract
The reaction of neamine tetraformamide tetra-acetate with phosphorous oxychloride and triethylamine has been studied. Isocyanide formation was found to proceed in stepwise fashion. The radical-induced reduction of the resultant derivatives by tri-n-butylstannane leads to the corresponding deaminatied aminoglycoside derivatives. In this way five new derivatives of neamine have been prepared for (eventual) biological evaluation.
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More From: Journal of the Chemical Society, Perkin Transactions 1
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