Reactions of malonthioamides and malonamidines with methyl acetylpyruvate as a one-step method to prepare 4-thio- and 4-aminopyrrolo[3,4- c]pyridines

Vera S Berseneva,Vasiliy A Bakulev,Wim Dehaen,Suzanne Toppet,Marina Borovkova

doi:10.1016/j.tet.2007.03.054

Reactions of malonthioamides and malonamidines with methyl acetylpyruvate as a one-step method to prepare 4-thio- and 4-aminopyrrolo[3,4- c]pyridines

Vera S Berseneva, Vasiliy A Bakulev + Show 3 more

https://doi.org/10.1016/j.tet.2007.03.054

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Journal: Tetrahedron	Publication Date: Mar 13, 2007
Citations: 15

Affiliation: KU Leuven

#HMQC Spectra #Structural Proof + Show 7 more

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Abstract

We report an efficient one-step approach to 4-thio and 4-aminopyrrolo[3,4- c]pyridines based on the selective reaction of malonthioamides and malonamidines with methyl acetylpyruvate. Structural proof is given by HMBC and HMQC spectra. A cascade heterocyclization mechanism is proposed for the reactions studied.

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