Abstract
Ketones and esters ( 4) were effectively prepared by reaction of Grignard reagents with acyl tributylphosphonium chlorides ( 2), diethyl acylphosphonates ( 5), or diisopropyl acylphosphonate ( 6) derived from acid chlorides and chloroformates ( 1). Although by the method with 2, 4 is prepared in one-pot operation from 1 and generally in a higher yield, the method with 5 or 6 proved to compensate for the synthesis of 4 with 2 in some respects. The reactivities of 2, 5, and 6 as electrophiles were also evaluated by comparing their reduction potentials with those of acid chlorides.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
