Abstract
The stable products of reactions of mucochloric acid and some of its ethers with 2-mer-captoacetic acid were synthesized and characterized. The variation of experimental conditions allowed targeted introduction of a sulfur- containing fragment into particular position of the heterocycle: the reaction in aqueous potassium hydroxide gives 3-substituted 2(5H)-furanone the triethylamine additive in nonaqueous solvents facilitates the formation of 4-substituted products, and acid catalysis results in the replacement of the hydroxy (methoxy) group at C(5). (3,4-Dichloro-2-oxo-2,5-dihydrofuran-5-ylthio)ethanoic acid and (3-chloro-5-hydroxy-2oxo-2,5dihydrofuran-4-ylthio)ethanoic acid were characterized by X-ray diffraction; their crystal and gas-phase structures were discussed. The 5-monosubstituted product crystallizes as a racemate, while 4monosubstituted product, as a conglomerate.
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