Reactions of 2-(trifluoroacetyl)chromones with aromatic amines

Abstract

Aromatic amines reacted with 2-(trifluoroacetyl)chromones as С- or N-nucleophiles, depending on the conditions. When the reaction was performed under solvent-free conditions at 100°С for 12–18 h, they acted as С-nucleophiles and gave bishetarylcarbinols in 21–67% yields, while in refluxing toluene the addition of primary arylamines occurred via the amino group, providing the corresponding hemiaminals (80–86%).