Abstract
With toxins prepared in this laboratory from a strain of a scarlet fever streptococcus received from Doctor Dochez, no skin reactions were induced in rats, mice, guinea-pigs, kittens, chickens, pigeons, monkeys, sheep or a calf. Questionable reactions were obtained in two young pigs with undiluted toxin and also in four rabbits out of eighteen, the remaining fourteen giving no reactions.Definite skin reactions, however, have been induced in white goats. All fourteen goats tested gave reactions to the toxin, but individual goats appeared to vary in susceptibility. With ten, definite reactions were obtained with 0.2 cc. of a 1:500 dilution of a toxin which gives a reaction in a 1:1000 dilution in a susceptible human being. Four other goats gave reactions to lower dilutions, varying from 1:50 to 1:250. The reactions in goats reached a maximum in 18 to 24 hours and at this stage were usually quite similar to those observed in human beings. In the more susceptible goats according to the potency of the material...
Published Version
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