Abstract
Low-energy electrons (LEEs) at energies of less than 2 eV effectively decompose 4-nitroimidazole (4NI) by dissociative electron attachment (DEA). The reactions include simple bond cleavages but also complex reactions involving multiple bond cleavages and formation of new molecules. Both simple and complex reactions are associated with pronounced sharp features in the anionic yields, which are interpreted as vibrational Feshbach resonances acting as effective doorways for DEA. The remarkably rich chemistry of 4NI is completely blocked in 1-methyl-4-nitroimidazole (Me4NI), that is, upon methylation of 4NI at the N1 site. These remarkable results have also implications for the development of nitroimidazole based radiosensitizers in tumor radiation therapy.
Highlights
Low-energy electrons (LEEs) at energies of less than 2 eV effectively decompose 4-nitroimidazole (4NI) by dissociative electron attachment (DEA)
It has been demonstrated that one single electron at an energy near 2 eV can induce the excision of CNÀ from acetamide, which proceeds by a complex reaction associated with the concerted cleavage of several bonds and the formation of new molecules.[5]
Beams experiment and mass spectrometric detection of the anions formed. We find that both molecules show a remarkably high sensitivity towards LEEs in the energy range 0–6 eV in the way that a variety of fragment anions are observed arising from unimolecular decomposition reactions
Summary
Low-energy electrons (LEEs) at energies of less than 2 eV effectively decompose 4-nitroimidazole (4NI) by dissociative electron attachment (DEA). Low-energy electrons (LEEs) can induce remarkably selective reactions in molecules,[1,2] which is based on the initial formation of an intermediate metastable electron–molecule compound (MCÀ#; M = molecule).
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