Reactions Catalysed by a Combination of Metals and Enzymes

Abstract

This chapter includes all the major progress in the field of enantioselective chemoenzymatic tandem reactions catalysed by a combination of metals and enzymes, not based on dynamic kinetic resolution for the first section, and based on dynamic kinetic resolution for the second section. In this powerful second approach, the enzyme acts as an enantioselective resolving catalyst and the metal serves as a fast racemising catalyst of the substrate. This second section, dealing with dynamic kinetic resolutions, is divided into two paragraphs dealing with ruthenium and enzyme-catalysed dynamic kinetic resolutions, and enzymatic dynamic kinetic resolutions using metals other than ruthenium. The first paragraph dedicated to the use of ruthenium as metal is subdivided into two parts which deal successively with dynamic kinetic resolutions of alcohols, and dynamic kinetic resolutions of amines. The second paragraph dedicated to the use of metals other than ruthenium is subdivided into three parts which deal successively with dynamic kinetic resolutions of alcohols, dynamic kinetic resolutions of amines, and dynamic kinetic resolutions of allylic acetates. This chapter well illustrates the power of enantioselective tandem reactions catalysed by combinations of metals with enzymes. The versatility of the combination of enzymes with metal catalysts is particularly well demonstrated by highly efficient chemoenzymatic dynamic kinetic resolutions.