Abstract
The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder.
Highlights
Polygenic Score (PGS) is the combined measure of a larger number of risk genes for any disease
We evaluated the association between cognition and hazardous drinking Polygenic Scores (PGS) by using four different cognition variables: median and standard deviation of Reaction Time (RT), Paired Associative Learning (PAL) First Trial Memory Score (FTMS), and PAL TEA
Most of the participants were on psychotropic medication
Summary
Polygenic Score (PGS) is the combined measure of a larger number of risk genes for any disease. Light to moderate alcohol use has been found to be associated with a decreased risk of cognitive impairment [9] in the normal population. This J-shaped relationship between alcohol use and cognition could be attributed to potential abstainer errors [10,11,12,13] and reverse causality bias [14]. There was no statistically significant association, whether positive or negative, between hazardous drinking PGS and reaction time or visual memory in male and female schizophrenia and schizoaffective disorder patients, after adjustment with age, age of onset, education, household pattern, and depressive symptoms (Table 4).
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