Abstract
Kinetics of the decomposition of racemic ibuprofen crystals were studied by non-isothermal analysis. Thermogravimetric analysis revealed that ibuprofen is thermally stable up to 152.6°C and the initial loss of mass was due to evaporation only. Activation energy, pre-exponential factor, activation entropy and Gibbs free energy for the decomposition of ibuprofen were determined using the integral method of Coats-Redfern (CR). Geometrical contraction models were found to be the best fits. The Arrheinus equation for the thermal decomposition of ibuprofen is k = (1.1 × 107) e–79125/RT sec–1.
Highlights
Thermal analysis is one of the most frequently used instrumental techniques in the pharmaceutical research
Kinetic analysis has been the subject of interest for many investigators involved in the field of thermal decomposition
Various methods were proposed for the kinetic study of the thermal decomposition of materials and are generally classified under model-fitting and model-free methods
Summary
Thermal analysis is one of the most frequently used instrumental techniques in the pharmaceutical research. Determination of the kinetic parameters helps to estimate the thermal stability [3] and the shelf-life of drugs. Kinetic analysis has been the subject of interest for many investigators involved in the field of thermal decomposition. Solid-state kinetics studies have increasing importance in thermal analysis and being helpful in the calculation of the parameters of Arrhenius equation and to determine the mechanism of decomposition reaction. (2014) Reaction Rate Models for the Thermal Decomposition of Ibuprofen Crystals. The kinetic parameters of ibuprofen were determined by Bogdan Tita et al [5] earlier. Since single crystal is the purest form of a compound, ibuprofen was synthesized from crystalline powder. Ibuprofen single crystals were grown by gel growth method. The kinetic parameters were determined for various solid state reaction models using the CR method under non-isothermal condition. Gibbs free energy and the entropy of activation were calculated
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