Reaction of VX and GD with gaseous ozone †

Abstract

Attempts at decontaminating nerve agents VX {O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothioate} and GD (pinacolyl methylphosphonofluoridate) with gaseous ozone are described. VX reacts like a tertiary amine with oxidation occurring at carbons adjacent to the nitrogen. In this manner a variety of novel VX derivatives still possessing intact P–S bonds are generated, and as such, must be considered to retain formidable toxicity. The major product is O-ethyl S-[2-(isopropylamino)ethyl] methylphosphonothioate. No reaction of GD with ozone occurs under the conditions employed.