Abstract
99 A number of pyrimidine derivatives (6 methyl uracil, 5 fluorouracil, 5 hydroxy 6 methyluracil) are pharmaceuticals exhibiting a wide spectrum of activ ity. The efficacy of pharmaceuticals as antioxidants is one of the main characteristics of their biological activity. However, the mechanism of inhibition of free radical induced chain oxidation by uracils has been poorly studied. The primary event of attack of poten tial antioxidant molecule by peroxyl radical plays an important role in the mechanism of oxidation retarda tion because it affects further reaction course. It is known [1] that the free radical oxidation of virtually equimolar amounts of 2,2' azobis(2 methylpropion amide) dihydrochloride and 5 methyluracil with atmospheric oxygen for 25 h at 313 K leads to the fol lowing products:
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