Reaction of Hydrazonoyl Halides 52:1 Synthesis and Antimicrobial Activity of Some New Pyrazolines and 1,3,4-Thiadiazolines

Abstract

[5-Substituted 2-(3-phenyl-5-substituted 2-pyrazolinyl)(1,3-thiazol-4-yl)] phenyldiazene and 2,3-dihydro-1,3,4-thiadiazoles were synthesized via reactions of hydrazonoyl halides with 5-substituted-3-phenyl-4,5-dihydropyrazole-1-carboximidothionic acid and {[2-2-}aza-2-((methylthioxomethyl)-amino]-vinyl}phenyl)-1-azavinyl]amino}methylthiomethane-1-thione, respectively. All structures of the newly synthesized compounds were elucidated by elemental analysis, spectral data, X-ray single crystal, and alternative synthesis methods whenever possible. Some of the new compounds were tested towards bacteria. In general, all tested compounds were capable of a high inhibiting the growth of gram positive and gram negative.