Abstract
VIRTUALLY all human subjects treated with insulin shortly develop circulating insulin-binding antibodies that are demonstrable by a variety of technics employing I131-labeled insulin.1 2 3 The formation of insulin-antibody complexes in human antiserums is a reversible reaction for which various kinetic and thermodynamic constants have been determined quantitatively.4 Insulin-binding capacities of antiserums from subjects that are not clinically resistant to insulin rarely exceed 10 to 20 units of insulin per liter of plasma whereas binding capacities of all but 1 of 54 antiserums from insulin-resistant subjects ranged from 57 to 4700 units per liter.5 Although individual antiserums showed similar insulin-binding capacities . . .
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
