Abstract
Various procedures were attempted in order to prepare α,β,γ,δ-unsaturated nitriles via the Wittig-Horner reaction of β-substituted cyclohex-2-en-1-ones with diethyl cyanomethyl phosphonate. Among them, the one using NaH as base in refluxing THF gives only the products resulting from carbonyl attack, in good yields. The stereochemistry of the reaction is discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have