Abstract
Alterations in type 1 cannabinoid (CB1) receptor are implicated in psychiatric disorders such as schizophrenia. CB1 participates in both depolarization-induced suppression of inhibition (DSI) and depolarization-induced suppression of excitation (DSE), suggesting its involvement in both inhibitory and excitatory circuits. However, previous studies describing the distribution of CB1 in human and non-human primate cortex utilized antibodies that preferentially targeted CB1 at inhibitory boutons. Given CB1’s role in both DSI and DSE, understanding cell-type specific CB1 distribution may increase our insight into its regulation of excitatory-inhibitory balance. Here, we investigate CB1 distribution in both inhibitory and excitatory boutons using quantitative fluorescent microscopy.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
