Abstract
Alterations in type 1 cannabinoid (CB1) receptor are implicated in psychiatric disorders such as schizophrenia. CB1 participates in both depolarization-induced suppression of inhibition (DSI) and depolarization-induced suppression of excitation (DSE), suggesting its involvement in both inhibitory and excitatory circuits. However, previous studies describing the distribution of CB1 in human and non-human primate cortex utilized antibodies that preferentially targeted CB1 at inhibitory boutons. Given CB1’s role in both DSI and DSE, understanding cell-type specific CB1 distribution may increase our insight into its regulation of excitatory-inhibitory balance. Here, we investigate CB1 distribution in both inhibitory and excitatory boutons using quantitative fluorescent microscopy.
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