Abstract
Re: Testosterone Therapy in Men with Biochemical Recurrence and Metastatic Prostate Cancer: Initial Observations
Highlights
Testosterone replacement therapy (TRT) has been a topic of controversy since its beginnings almost 90 years ago.[1]
Employed to reverse age-related ailments and as a fountain-of-youth treatment, there was a pendulum shift with the Huggins and Hodges proposal that testosterone activates prostate cancer growth.[2]
In 1981, Fowler and Whitmore reported that 45 of 52 men with metastatic prostate cancer (MET) who received testosterone demonstrated an unfavorable response within 30 days.[3]
Summary
Testosterone replacement therapy (TRT) has been a topic of controversy since its beginnings almost 90 years ago.[1]. Testosterone replacement therapy (TRT) has been a topic of controversy since its beginnings almost 90 years ago.[1] Initially employed to reverse age-related ailments and as a fountain-of-youth treatment, there was a pendulum shift with the Huggins and Hodges proposal that testosterone activates prostate cancer growth.[2]
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